Lutetium in PDB 7zu8: Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4.

Enzymatic activity of Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4.

All present enzymatic activity of Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4.:
3.4.21.19;

Protein crystallography data

The structure of Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4., PDB code: 7zu8 was solved by L.Del Amo-Maestro, U.Eckhard, A.Rodriguez-Banqueri, S.R.Mendes, T.Guevara, F.X.Gomis-Ruth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	63.51 / 2.05
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	86.65, 93.35, 48.69, 90, 90, 90
*R / R_free (%)*	20.9 / 25

Lutetium Binding Sites:

The binding sites of Lutetium atom in the Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4. (pdb code 7zu8). This binding sites where shown within 5.0 Angstroms radius around Lutetium atom.
In total 2 binding sites of Lutetium where determined in the Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4., PDB code: 7zu8:
Jump to Lutetium binding site number: 1; 2;

Lutetium binding site 1 out of 2 in 7zu8

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Lutetium Binding Sites List in 7zu8

Lutetium binding site 1 out of 2 in the Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4.

Mono view

Stereo pair view

A full contact list of Lutetium with other atoms in the Lu binding site number 1 of Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Lu501 b:51.7 occ:0.61	LU1	A:K93501	0.0	51.7	0.6
	O	A:ACT502	2.4	35.7	0.6
	OXT	A:ACT502	2.4	36.0	0.6
	O25	A:K93501	2.4	35.8	0.6
	O28	A:K93501	2.4	35.8	0.6
	N23	A:K93501	2.5	35.6	0.6
	N09	A:K93501	2.5	35.2	0.6
	N17	A:K93501	2.5	35.9	0.6
	N02	A:K93501	2.6	35.6	0.6
	N06	A:K93501	2.6	35.9	0.6
	C03	A:K93501	2.7	35.2	0.6
	C	A:ACT502	2.7	35.9	0.6
	C01	A:K93501	3.2	35.4	0.6
	C24	A:K93501	3.3	36.1	0.6
	C18	A:K93501	3.3	35.8	0.6
	C22	A:K93501	3.3	35.5	0.6
	C16	A:K93501	3.4	35.9	0.6
	C29	A:K93501	3.4	35.1	0.6
	C07	A:K93501	3.4	35.7	0.6
	C11	A:K93501	3.4	35.1	0.6
	C10	A:K93501	3.5	35.8	0.6
	C08	A:K93501	3.5	35.3	0.6
	C04	A:K93501	3.5	35.9	0.6
	C30	A:K93501	3.5	35.8	0.6
	C05	A:K93501	3.5	36.0	0.6
	CH3	A:ACT502	4.3	36.1	0.6
	O26	A:K93501	4.5	37.1	0.6
	O27	A:K93501	4.5	35.6	0.6
	C21	A:K93501	4.7	35.3	0.6
	C15	A:K93501	4.7	35.7	0.6
	C19	A:K93501	4.7	35.0	0.6
	OG	A:SER367	4.8	57.4	1.0
	C13	A:K93501	4.8	35.6	0.6
	N	A:SER367	4.9	51.6	1.0

Lutetium binding site 2 out of 2 in 7zu8

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Lutetium Binding Sites List in 7zu8

Lutetium binding site 2 out of 2 in the Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4.

Mono view

Stereo pair view

A full contact list of Lutetium with other atoms in the Lu binding site number 2 of Crystal Structure of the Zymogen Form of the Glutamic-Class Prolyl- Endopeptidase Neprosin at 2.05 A Resolution in Presence of the Crystallophore Lu-XO4. within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Lu503 b:56.9 occ:0.49	LU1	A:K93503	0.0	56.9	0.5
	OE2	A:GLU89	2.4	70.0	1.0
	OE1	A:GLU89	2.4	67.0	1.0
	O25	A:K93503	2.4	42.4	0.5
	O28	A:K93503	2.4	41.8	0.5
	N23	A:K93503	2.5	41.4	0.5
	N17	A:K93503	2.5	41.5	0.5
	N06	A:K93503	2.6	41.2	0.5
	N09	A:K93503	2.6	41.6	0.5
	N02	A:K93503	2.6	41.3	0.5
	CD	A:GLU89	2.7	66.4	1.0
	C07	A:K93503	3.2	41.5	0.5
	C03	A:K93503	3.3	41.4	0.5
	C24	A:K93503	3.3	41.5	0.5
	C18	A:K93503	3.3	41.3	0.5
	C22	A:K93503	3.3	41.4	0.5
	C16	A:K93503	3.3	41.4	0.5
	C11	A:K93503	3.4	41.4	0.5
	C29	A:K93503	3.4	41.6	0.5
	C10	A:K93503	3.4	41.6	0.5
	C30	A:K93503	3.5	41.4	0.5
	C08	A:K93503	3.5	41.7	0.5
	C04	A:K93503	3.5	41.1	0.5
	C01	A:K93503	3.5	41.4	0.5
	C05	A:K93503	3.6	41.4	0.5
	CG	A:GLU89	4.2	59.2	1.0
	O26	A:K93503	4.5	40.9	0.5
	O27	A:K93503	4.5	41.2	0.5
	C21	A:K93503	4.7	41.4	0.5
	C15	A:K93503	4.7	41.5	0.5
	C19	A:K93503	4.7	41.3	0.5
	N	A:GLU89	4.8	54.4	1.0
	C13	A:K93503	4.8	41.4	0.5
	O	A:LYS87	4.8	62.9	1.0
	O	A:HOH683	4.8	40.4	1.0
	CB	A:GLU89	5.0	54.9	1.0

Reference:

L.Del Amo-Maestro, S.R.Mendes, A.Rodriguez-Banqueri, L.Garzon-Flores, M.Girbal, M.J.Rodriguez-Lagunas, T.Guevara, A.Franch, F.J.Perez-Cano, U.Eckhard, F.X.Gomis-Ruth. Molecular and in Vivo Studies of A Glutamate-Class Prolyl-Endopeptidase For Coeliac Disease Therapy. Nat Commun V. 13 4446 2022.
ISSN: ESSN 2041-1723
PubMed: 35915115
DOI: 10.1038/S41467-022-32215-1

Page generated: Wed Apr 5 10:49:16 2023

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